The fact that various immune cells, including macrophages, can be found in tumor tissue has long been known. With the recent introduction of the novel concept of macrophage differentiation into a classically activated phenotype M1 and an alternatively activated phenotype M2 , the role of tumor-associated macrophages TAMs is gradually beginning to be elucidated. Specifically, in human malignant tumors, TAMs that have differentiated into M2 macrophages act as "protumoral macrophages" and contribute to the progression of disease. Based on recent basic and preclinical research, TAMs that have differentiated into protumoral or M2 macrophages are believed to be intimately involved in the angiogenesis, immunosuppression, and activation of tumor cells. In this paper, we specifically discuss both the role of TAMs in human malignant tumors and the cell-cell interactions between TAMs and tumor cells. Abstract The fact that various immune cells, including macrophages, can be found in tumor tissue has long been known. Publication types Research Support, Non-U.
March 16, report. A large team of researchers affiliated with a host of institutions in Europe and the U. In their paper published in the journal Science Immunology , the group describes their work involving transcriptional and epigenetic profiling of natural killer NK cells and what they learned about them. NK cells play a role in the immune system , carrying out a wide range of functions related to combatting viral infections and also in responding to the development of cancer. In this new effort, the researchers sought to better understand NK cell differentiation, during which they undergo gene expression changes that allow them to play more specific roles in an immune response.
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