Human impact on the environment or anthropogenic impact on the environment includes changes to biophysical environments  and to ecosystems , biodiversity , and natural resources   caused directly or indirectly by humans, including global warming ,   environmental degradation  such as ocean acidification   , mass extinction and biodiversity loss ,     ecological crisis , and ecological collapse. Modifying the environment to fit the needs of society is causing severe effects. Some of the problems, including global warming and biodiversity loss pose an existential risk to the human race,   and some experts attribute this crisis to overall human overpopulation. The term anthropogenic designates an effect or object resulting from human activity. The term was first used in the technical sense by Russian geologist Alexey Pavlov , and it was first used in English by British ecologist Arthur Tansley in reference to human influences on climax plant communities.
Metrics details. Pilot studies for phase III trials - which are comparative randomized trials designed to provide preliminary evidence on the clinical efficacy of a drug or intervention - are routinely performed in many clinical areas. Also commonly know as "feasibility" or "vanguard" studies, they are designed to assess the safety of treatment or interventions; to assess recruitment potential; to assess the feasibility of international collaboration or coordination for multicentre trials; to increase clinical experience with the study medication or intervention for the phase III trials. They are the best way to assess feasibility of a large, expensive full-scale study, and in fact are an almost essential pre-requisite. Conducting a pilot prior to the main study can enhance the likelihood of success of the main study and potentially help to avoid doomed main studies.
The study will evaluate the safety and performance of the CPNS in patients suffering from Acute Decompensated Heart Failure, defined as new or worsening symptoms of heart failure. Up to fifty patients are expected to be enrolled worldwide. The Cardionomic Pulmonary Neuromodulation System is founded on the principle that sympathetic nerve stimulation induces cardiac contractility. The System is comprised of a stimulation console and a minimally invasive catheter that delivers targeted endovascular stimulation to the pulmonary artery.
Recognized as one of the most cited methodology books in the social sciences, the Sixth Edition of Robert K. Yin's bestselling text provides a complete portal to the world of case study research. With the integration of 11 applications in this edition, the book gives readers access to exemplary case studies drawn from a wide variety of academic and applied fields.